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RGUHS Nat. J. Pub. Heal. Sci Vol: 14  Issue: 2 eISSN:  pISSN

Original Article

Central nervous system manifestations and its outcome in Dengue fever

Gayathri H Aradhya*, Saurabh Kumar

*Associate Professor Paediatrics, JJM Medical College, Davangere

 

Corresponding author:

Dr Gayathri H Aaradhya Associate Professor of Paediatrics Davangere 570 004, Karnataka 

Year: 2015, Volume: 5, Issue: 4, Page no. 152-154,
Views: 689, Downloads: 7
Licensing Information:
CC BY NC 4.0 ICON
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0.
Abstract

Dengue infection is one of the important tropicai infectious diseases T h e occurrence of neuroiogical manifestations in dengue infection has been recognized for iong. Recently the direct neurotropic potential of the virus has been recognized. Hence a study was conducted to find out the incidence of CNS manifestations in children with dengue, spectrum of neurological manifestations and presence of dengue specific IgM antibodies in the CSF. Methodology: 100 patients who were admitted to our two teaching hospitals, in the age group of 6 months to 15 years, who showed signs and symptoms of dengue fever and who had positive IgM levels in the blood were included in the study. Children who presented with neurological symptoms were separately grouped and CSF analysis, specially IgM was done in this group. Results: The neurological incidence in our study was 40 %. Seizures were present in 70% and altered sensorium was present in 80 % of cases. Papilloedema, and cranial nerve palsies were observed in 30 % of cases and meningeal signs were present in 80 % of cases. CSF protein was high in 80 % of cases and pleocytosis was presentin 80 % of cases. CSF IgM was positive in 35 % of cases. In ourstudy, mortality was 4 (4 %). Interpretation and Conclusion: Dengue fever encompasses an expanding clinical spectrum not just restricted to WHO specified criteria for making a diagnosis of other than DHF or DSS. It frequently involves encephalitis probably due to a direct neutrotropic effect of dengue virus. 

<p>Dengue infection is one of the important tropicai infectious diseases T h e occurrence of neuroiogical manifestations in dengue infection has been recognized for iong. Recently the direct neurotropic potential of the virus has been recognized. Hence a study was conducted to find out the incidence of CNS manifestations in children with dengue, spectrum of neurological manifestations and presence of dengue specific IgM antibodies in the CSF. Methodology: 100 patients who were admitted to our two teaching hospitals, in the age group of 6 months to 15 years, who showed signs and symptoms of dengue fever and who had positive IgM levels in the blood were included in the study. Children who presented with neurological symptoms were separately grouped and CSF analysis, specially IgM was done in this group. Results: The neurological incidence in our study was 40 %. Seizures were present in 70% and altered sensorium was present in 80 % of cases. Papilloedema, and cranial nerve palsies were observed in 30 % of cases and meningeal signs were present in 80 % of cases. CSF protein was high in 80 % of cases and pleocytosis was presentin 80 % of cases. CSF IgM was positive in 35 % of cases. In ourstudy, mortality was 4 (4 %). Interpretation and Conclusion: Dengue fever encompasses an expanding clinical spectrum not just restricted to WHO specified criteria for making a diagnosis of other than DHF or DSS. It frequently involves encephalitis probably due to a direct neutrotropic effect of dengue virus.&nbsp;</p>
Keywords
Dengue fever, encephalitis, encephalopathy, CNS manifestation of dengue.
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