Background: Dermatological conditions significantly affect patients’ quality of life and are frequently associated with psychiatric comorbidities such as depression and anxiety. Understanding the sociodemographic, dermatological, and psychiatric profiles of the affected individuals is essential for providing holistic care. Objective: To evaluate the sociodemographic characteristics, dermatological profiles, and psychiatric comorbidities of patients attending a dermatology outpatient department and examine the association between quality of life and psychiatric parameters. Methods: This cross-sectional study included 114 patients with dermatological disease. Data were collected using validated tools including the Dermatology Life Quality Index (DLQI), Patient Health Questionnaire-9 (PHQ-9), Hamilton Depression Rating Scale (HAM-D), Generalized Anxiety Disorder-7 (GAD-7), and Patient Health Questionnaire-15 (PHQ-15). Descriptive statistics were used to summarize the data, and associations were analyzed using chi-squared tests, logistic regression, and correlation analysis. Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive utility of PHQ-9 for high DLQI scores. Results: The majority of the patients were young, unmarried, and urban residents, with acne (36.0%) and fungal infections (27.2%) being the most common dermatological conditions. Psychiatric comorbidities were prevalent, with 60.5% of participants experiencing depression and 44.7% reporting anxiety. Higher DLQI scores were significantly associated with the PHQ-9 (p < 0.05), HAM-D (p < 0.05), and GAD-7 (p < 0.05) scores. Logistic regression identified the PHQ-9 and HAM-D as independent predictors of high DLQI scores (p < 0.05). ROC analysis of the PHQ-9 yielded an AUC of 0.72, suggesting moderate accuracy in predicting an impaired quality of life. Conclusion: Dermatological conditions are associated with significant psychiatric comorbidities and quality-of-life impairments. Depression and anxiety are key predictors of poor quality of life. These findings emphasize the need for integrated dermatology and mental healthcare to address the holistic needs of patients.

Introduction: Eosinophilic cystitis (EC) is a rare inflammatory condition of the urinary bladder characterized by a predominant infiltration of eosinophils into the bladder wall. About 200 cases of eosinophilic cystitis have been reported till date. The pathogenesis of EC remains uncertain, but it is often linked to allergic reactions, parasitic infections, and certain medications. Clinical Features: The three patients described in this series presented with lower urinary tract symptoms (LUTS) and hematuria. Diagnosis, Interventions and Outcomes:Diagnosis was ascertained by cystoscopy and tissue biopsy. In all three cases, the lesion was completely excised and submitted for histopathological examination.All three patients received oral antihistaminics for 3 weeks and one patient received oral prednisolone. All three patients had shown no recurrence during follow up Conclusions: A combination of imaging studies, urinalysis, and histopathological biopsy can effectively confirm the condition. In our case series, early diagnosis and appropriate treatment led to favorable outcomes.

Abstract: Fetus in fetu is a rare congenital anamoly. The incidence of this condition accounts upto 1 in 5,00,000 live births. We report a case of A 5-month-old female child presented with gross abdominal distension with respiratory distress. A contrast CT of the abdomen was performed which revealed a well encapsulated multiloculated solid cystic lesion with intralesional fatty components as well as calcifications forming appendiceal bones was seen in the right retroperitoneum. Exploratory laparotomy was performed and the lesion was excised in toto and the patient is on regular followup. Since Fetus in fetu by itself is a rare entity, we make an attempt to report the same as well as give some insights about the condition.

Abstract: Hyalohyphomycosis is an opportunistic infection of subcutaneous tissue caused by hyaline fungi (Hyphomycetes) that form septate hyphae in tissue. Immunocompromise and tropical climate are the main predisposing factors. Rhino-orbital Hyalohyomycosis involving the Paranasal sinus and orbit in an immunocompetent host is a very rare presentation. We discuss the case of a 27-year-old male, crop surveyor by occupation who presented with proptosis and double vision of the left eye. After collecting history and clinical examination patient was subjected to CECT PNS + Orbit and contrast MRI PNS + Orbit which was suggestive of Pseudotumor or orbital fungal mass/ Mucor mycosis. The patient was managed by Endoscopic sinus surgery and excision of orbital mass via Denker's approach under general anaesthesia, and diagnosis was confirmed by histopathology as hyalohyphomycosis. Post-surgery anti-fungal medication (Itraconazole), and nasal saline irrigation. Though a rare and unique presentation in an immunocompetent individual, Rhino-orbital Hyalohyphomycosis is to be considered as one of the differential diagnoses for unilateral intra-orbital mass/ proptosis.

Abstract: Transverse myelitis is one of the rare neurological presentations of Antiphospholipid antibody syndrome and most of the previously reported cases are acute to subacute presentation, while chronic presentation is extremely rare and poses a clinical challenge to diagnosis. We present a case of middle aged female with a prior history of unprovoked deep vein thrombosis of right lower limb, who presented to us with gradually progressive clinical features suggesting non compressive cervical myelopathy. Her blood investigation showed triple positive antiphospholipid antibodies profile with no clinical or immunological features suggestive of commonly associated SLE. She was treated with high dose steroids and mycophenolate Mofetil. She had mild to moderate clinical improvement in symptoms at 6 months follow-up.