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Original Article

Characterization of Mast cells in Periapical Lesions: A Birds Eye View

Ramya B Jagadeesh1 , Abhishek Jahagirdar2 , Ahmed Mujib Bangalore Rahim3 , Pavan Gurunathrao Kulkarni 

1 Senior Lecturer, Department of Pedodontics and Preventive Dentistry, DAPMRV Dental College and Hospital, Bangalore, 

2Senior Lecturer, Department of Oral Pathology and Microbiology, Sri Rajiv Gandhi College of Dental Sciences, Bangalore,

3  Professor and Head, 4Assistant Professor

Department of Oral Pathology and Microbiology, Bapuji Dental College and Hospital, Davangere 

Year: 2013, Volume: 3, Issue: 2, Page no. 105-109,
Views: 922, Downloads: 7
Licensing Information:
CC BY NC 4.0 ICON
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0.
Abstract

The inflammatory infiltrate of periapical lesions is composed mostly of plasmocytes, lymphocytes, macrophages, fibroblasts, endothelial cells and mast cells. The versatile role of mast cells in allergy and immune responses is well recognized but their participation in the pathogenesis of periapical lesions is not fully clear.

The aim of this study is to quantify the mast cell numbers in periapical lesions to clarify their role in the pathogenesis of these lesions. 66 periapical lesions were stained with hematoxylin-eosin, histochemical Giemsa and tolonium chloride (toluidine blue) technique. Mast cell count below 100 on 1000 fields of high power magnification was noted as negative, 101-400 as mild, 401-800 as moderate and over 800 cells as severe. Mast cells were found in 57 (86.36%) lesions. The presence of mast cells was greater in cysts than in granulomas (P=0.03). Mast cells were present in both the inflammatory infiltrate and fibroblastic areas of periapical lesions with degranulation as a frequent finding in these zones. Their presence was mostly frequently moderate.

Our results suggest that mast cells play an active role in the pathogenesis of the periapical inflammatory lesions. The findings suggest a role of mast cells in regulation of cellular and immune mechanisms in periapical lesions, balancing between inflammatory and reparatory processes in inflamed periapical tissue.

<p>The inflammatory infiltrate of periapical lesions is composed mostly of plasmocytes, lymphocytes, macrophages, fibroblasts, endothelial cells and mast cells. The versatile role of mast cells in allergy and immune responses is well recognized but their participation in the pathogenesis of periapical lesions is not fully clear.</p> <p>The aim of this study is to quantify the mast cell numbers in periapical lesions to clarify their role in the pathogenesis of these lesions. 66 periapical lesions were stained with hematoxylin-eosin, histochemical Giemsa and tolonium chloride (toluidine blue) technique. Mast cell count below 100 on 1000 fields of high power magnification was noted as negative, 101-400 as mild, 401-800 as moderate and over 800 cells as severe. Mast cells were found in 57 (86.36%) lesions. The presence of mast cells was greater in cysts than in granulomas (P=0.03). Mast cells were present in both the inflammatory infiltrate and fibroblastic areas of periapical lesions with degranulation as a frequent finding in these zones. Their presence was mostly frequently moderate.</p> <p>Our results suggest that mast cells play an active role in the pathogenesis of the periapical inflammatory lesions. The findings suggest a role of mast cells in regulation of cellular and immune mechanisms in periapical lesions, balancing between inflammatory and reparatory processes in inflamed periapical tissue.</p>
Keywords
Mast cells; Radicular cyst; Periapical granuloma; Tolonium chloride.
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