RGUHS Nat. J. Pub. Heal. Sci Vol: 14 Issue: 4 eISSN: pISSN
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Muralidhar L.Kulkarni 1, Sidramayya SS 2, Vivekanand VV2 , Anish Desai 2, Hemalatha2
1Professor and Head, 2Resident, Department of Pediatrics, JJM Medical College, Davangere
Abstract
Haemophagocytic lymphohistiocytosis is a rare macrophage related hyperinflammatory disorder characterized by highly stimulated but inactive immune response. The disease may be inherited or acquired due to infections, collagen vascular disease and malignancies. The pathological hallmark of this disorder is aggressive proliferation of macrophages and histiocytes. The symptoms are due to high levels of cytokines secreted by immune effector cells which display functional defects. Recognizing the morphologic changes in the liver and the immunophenotypic feature of the infiltrate are critical for a rapid diagnosis and prompt initiation of treatment.We report a case of haemophagocytic lymphohistiocytosis as it is one of the emerging infectious diseases and review current literature.
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