RGUHS Nat. J. Pub. Heal. Sci Vol: 14 Issue: 4 eISSN: pISSN
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Malashree1 , Shashikala P2 , Kavita GU3 , Krishnamurthy L4 , Shanthakumar CJ5 , Sathyanarayan MVV6 , L S Patil7
Postgraduate student , Professor and HOD , Professor , Professor and HOD , Professor , Professor , 1,2,3 4 5,6 7 Department of Pathology , Neurology , Neurosurgery and Surgery , S.S Institute of Medical Sciences and Research Centre, Davangere.
Dr. Kavita GU
Professor, Department of Pathology
S.S Institute of Medical Sciences and Research
Centre, Davangere-577002
Email id: drgukavita@gmail.com
Abstract
Background: Peripheral nerve sheath tumors (PNST) are neuroectodermal in origin. More than 90–95% of PNST are benign. Neurofibromas and Schwannomas are the common benign PNSTs. Malignant peripheral nerve sheath tumor(MPNST) may originate de novo or in a plexiform neurofibroma associated with neurofibromatosis, but malignant transformation of a Schwannoma is exceptionally rare.
Methodology: Retrospective cohort study conducted over a period of five years in a tertiary care centre. Demographic details of PNSTcases retrieved from the records were analyzed.
Results: There were 40 specimens with a confirmed diagnosis of PNST from 40 patients who underwent surgery. Male to female ratio was 1.1:1. Most of the PNSTs were encountered in the age group of 21-50 years. Majority of the tumors i.e., 38(95%) were benign. MPNSTconstituted only 5% i.e., 2 cases. Head and neck (32.5%) was the common site for benign PNSTs.
Conclusion: This study concludes that majority of the PNSTs are benign. MPNSTis a rare tumor.
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